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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Low intensity ultrasound-mediated drug-loaded nanoparticles intravaginal drug delivery: an effective synergistic therapy scheme for treatment of vulvovaginal candidiasis

Fig. 3

Bio-safety analysis of US-mediated AmB-NPs in vitro and in vivo. The viability changes of macrophages A and L. crispatus B treated with US combined with AmB-NPs at 1.0 W/cm2 ultrasonic intensity irradiation for 5 min. The level of plasma urea nitrogen (BUN) C and creatinine (SCr) D in rabbit following treatment with free AmB and AmB-NPs at a dose of 5 mg/kg/day for three days via intravenously or intravaginally perfused respectively. E The pathological structural changes of vagina tissue after US alone or combined with AmB-NPs under different ultrasonic intensity and irradiation time in vivo, black arrows indicate damage to the vaginal mucosa, red arrows show submucosal inflammatory cell aggregation (scale bar = 100 μm). **P < 0.01, and ***P < 0.001

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Journal of Nanobiotechnology

ISSN: 1477-3155

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