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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Low intensity ultrasound-mediated drug-loaded nanoparticles intravaginal drug delivery: an effective synergistic therapy scheme for treatment of vulvovaginal candidiasis

Fig. 4

Permeability analysis of US-mediated nanoparticles on mucus and vaginal tissue. A The distribution of DiI red fluorescent nanoparticles in the vaginal cavity with or without US irradiation observed by CLSM (scale bar = 100 μm). B The quantitative calculation of the fluorescence intensity in the vaginal cavity and mucosal. C Observation of DiI nanoparticles penetration in vaginal tissue in vivo (scale bar = 100 μm), the nanoparticles were mainly distributed in the submucosal area after ultrasound irradiation but that were concentrated in the mucosal layer in the control group. D Quantitative analysis of permeability through the average area of red fluorescence intensity (5 randomly-selected view fields) in the mucosal layer and submucosal area of vagina tissue. ***P < 0.001

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Journal of Nanobiotechnology

ISSN: 1477-3155

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