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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Low intensity ultrasound-mediated drug-loaded nanoparticles intravaginal drug delivery: an effective synergistic therapy scheme for treatment of vulvovaginal candidiasis

Fig. 6

Histopathological and inflammatory changes of rabbit vaginas were observed by H&E staining (scale bar = 50 μm). The established VVC model vagina shown a biofilm-like structure formed by dense hyphae and C. albicans cells adhered to the mucosa (black arrows). On the seventh day period after different treatment, the control group also shown numerous colonies of hyphae in the vaginal cavity and further aggravated inflammatory symptoms with incomplete mucosa structure, inflammatory cells (red arrows) gathered and distributed under the mucosa. The AmB related treated group improved inflammatory infiltration. After US + AmB-NPs treatment, no obvious colonies and hyphae were residual in the cavity and the submucosal inflammatory cells were significantly reduced

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Journal of Nanobiotechnology

ISSN: 1477-3155

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