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Table 2 Antifungal susceptibility of US-mediated AmB and AmB-NPs on C. albicans planktonic cells with or without vaginal mucus barrier

From: Low intensity ultrasound-mediated drug-loaded nanoparticles intravaginal drug delivery: an effective synergistic therapy scheme for treatment of vulvovaginal candidiasis

 

Without vaginal mucus

With vaginal mucus

US (−)

US ( +)

US (−)

US ( +)

MIC

MFC

MIC

MFC (mg/l)

MIC

MFC

MIC

MFC

pH 7.2

        

 AmB

0.5

1

0.25

0.5

4

8

1

2

 AmB-NPs

0.5

1

0.125

0.25

2

4

0.5

1

pH 5.5

        

 AmB

1

2

0.5

1

8

16

2

4

 AmB-NPs

0.5

1

0.125

0.25

2

4

0.5

1

  1. US ultrasound, MIC minimal inhibitory concentration, MFC minimum fungicidal concentration, AmB Amphotericin B, AmB-NPs Amphotericin B-loaded PLGA-PEG nanoparticles