Fig. 8

PDA NPs exhibited excellent biocompatibility both in vitro and in vivo. a Bar graphs with dots showing viability of PC12 cells incubated with PDA NPs for 24 h [F (5, 12) = 2.336, P = 0.1061]. b Representative picture showing hemolytic reaction of red blood cells in different solutions: 1. PBS; 2. 200 μg/ml PDA NPs; 3. 0.2% Triton X-100. c Bar graphs with dots showing blood compatibility of PDA NPs [F (2, 6) = 1553, P < 0.0001]. d Representative histological images of main organs post treatments. Scale bar = 100 μm. Data are presented as the means ± SEM (n = 3 per group). Results were analyzed by one-way ANOVA followed by Bonferroni test for post hoc comparisons. (**): P < 0.01 versus indicated groups; (n.s.): not significant. PBS phosphate-buffered saline, PDA NPs polydopamine nanoparticles