Fig. 4

PLGA NPs deposition at stenosis sites promote inflammatory factors secretion. A IHC staining for TNF- α, IL-6, and IL-10 (scale bars, 20 µm). B Comparison of deposition of NPs in blood vessels. And the quantification of percentage of IL-10 positive expression (C); percentage of TNFα positive expression (E) and percentage of IL-6 positive expression (F) in different groups. D The quantification of NPs and CD31. *p < 0.05; **p < 0.01; ***p < 0.001 (n = 5)