Fig. 6
Antitumor efficacy of PH/PB/N/R in the PDX model. A Schematic illustration of the experimental design. B Schematic diagram of the human ErbB2-specific CAR structure. C In Vivo Imaging System (IVIS) spectrum images of the mice after PH/PB/N/R treatment on different days. D Survival curve of the PDX model mice treated with PH/PB/N/R. E In vivo T2-weighted MR images of tumor-bearing mice after each treatment. Both of the red circle and arrow in Fig. 6E point to the tumor site. The photos were processed with ImageJ software. F Weight changes in the PDX model mice treated with PH/PB/N/R. Data are presented as the mean ± SEM (n = 3). G Representative immunofluorescence images of tumors showing CD8 + T cell and CD80 + macrophage infiltration in the control and P/PB/N/R groups. Scale bars, 50 μm. Experiments were repeated three times