Fig. 6

Crosstalk between FGFRs and AR signalling during the formation of acne. A Quantification of AR transcriptional level in SZ95 cells treated with AR siRNA. One-way ANOVA was employed for statistical analysis. ***p < 0.001; B Growth inhibition in SZ95 cells induced by AR siRNA. One-way ANOVA was employed for statistical analysis. *p < 0.05; C Oil red O staining indicates that knockdown of AR reduced the sebum accumulation in SZ95 cells; D Quantification of TG in SZ95 cells treated with AR siRNA. One-way ANOVA was employed for statistical analysis. ***p < 0.001; E Western blotting analyzes the key molecules of FGFRs and AR signalling pathways in response to the knockdown of AR in SZ95 cells; F Western blotting analyzes the key molecules of FGFRs and AR signalling pathways in response to knockdown of FGFR2 in SZ95 cells