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Fig. 8 | Journal of Nanobiotechnology

Fig. 8

From: Hyaluronic acid-FGF2-derived peptide bioconjugates for suppression of FGFR2 and AR simultaneously as an acne antagonist

Fig. 8

HA-P5 and AZD4547 inhibited the AR translation in a YTHDF3-dependent manner in SZ95 cells. A qPCR quantified the expression of YTHDF3 in SZ95 cells treated with YTHDF3 siRNA. One-way ANOVA was employed for statistical analysis. ***p < 0.001; B Growth inhibition in SZ95 cells in response to knockdown of YTHDF3. One-way ANOVA was employed for statistical analysis. *p < 0.05; C Knockdown of YTHDF3 reduced the sebum accumulation in SZ95 cells as indicated by typical Oil red O staining images; D Quantification of TG in SZ95 cells treated with YTHDF3 siRNA. One-way ANOVA was employed for statistical analysis. **p < 0.01; E qPCR quantified the transcription of AR in SZ95 cells treated with YTHDF3 siRNA; F Western blotting analyzes the translation of AR protein in response to knockdown of YTHDF3 in SZ95 cells

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Journal of Nanobiotechnology

ISSN: 1477-3155

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