Table 1 Comparison of different nanomaterials in acne treatment
Nanomaterials | Component | Advantage | Disadvantage |
|---|---|---|---|
Liposomes | • Hydrophilic heads • Hydrophobic tails • Hydrophobic bilayer • Hydrophilic core | • Sustained drug release • Increase drug stability | • Low biodegradability • Low loading capacity • Gelation |
Microspheres | • Hydrophilic phase • Hydrophobic phase • Cosurfactant • Surfactant | • High keratin penetration • Increase skin hydration | • Low biodegradability • Low loading capacity • Irritation and sensitizing potential of surfactants |
Niosomes | • Antibody • Hydrophilic head • Hydrophobic tail • Hydrophobic drug | • Increase drug stability • Targeting | • Higher production cost • Lower-scale production |
Solid nanoparticles | • Lipid matrix • Small molecule drug | • Increase drug stability • High keratin penetration | • Low biodegradability • Low loading capacity |
HA-P5 | • Peptide • Hyaluronic acid | • Large-scale production • Low production cost • Higher biocompatible • Higher biodegradability • High keratin penetration | • Instability |