Fig. 5

a Fluorescence images of mice bearing A375 tumors and ex vivo fluorescence images of the major organs and tumors dissected from the mice after being treated with B-MN (control), MN-I, and MN-pB/I patches. b Semiquantitative biodistribution of nanoliposomes in the mice determined by averaging the fluorescence intensities from the images of the organs and tumors. c PA images of the tumor sites on the A375 tumor-bearing mice treated with the B-MN, MN-I, and MN-pB/I patches. d The corresponding PA signals at the tumor sites of the A375 tumor-bearing mice. e Thermal images of the A375 tumor-bearing mice from different treating groups (B-MN + laser, MN-I + laser, and MN-pB/I + laser) under 808 nm laser irradiation for 2 min. f Tumor volume curves of the different mice groups following treatment with B-MN, B-MN + laser, MN-pB, MN-I + laser, MN-pB/I, and MN-pB/I + laser. g Photographs of the tumor tissues removed from the groups treated with different formulations after 15 d. The red circles indicated that the tumors had disappeared. h Tumor weights of each group at the end of the experiment and IRT. i Body weight curves of the A375 tumor-bearing mice in each group. The data shown represent the mean ± SD, n = 3 per group. NS no significance. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001