Fig. 6

In vivo photothermal images and antitumor effect evaluation of MnGA-based mild-temperature PTT. a Schematic diagram of the in-vivo experiment to evaluate the anti-tumor effect of MnGA nanoparticles. b The representative thermal images of the mice with intravenous administration of PBS, FeGA, MnGA and CaGA (10 mg/kg) under NIR irradiation for 10 min (1.5 W/cm²). c The corresponding temperature changes over time curve of tumor regions with injection of PBS, FeGA, MnGA and CaGA. d Tumor volume growth curves of each group (n = 4). e The body weight changes in the four groups of mice. f The images of the tumors on day 14 after section. g H&E staining of tumor sections in four different groups. h TUNEL analysis of the tumor sections from various groups on the 14th day of the experiments. Scale bars: g, h) 100 μm. ns: no significance, ***p < 0.001