Fig. 5

A Histological analysis of tumor tissues stained with hematoxylin and eosin, Ki-67, and cleaved caspase-3 from these groups. Tumors treated with Se-MnP and OX@Se-MnP exhibit typical apoptotic appearance (cell shrinkage, karyolysis and nuclear fragmentation), poor cell proliferation and higher cleaved caspase-3 expression, comparing with free PBS treatments. B Histological analysis of tumor tissues stained with ABCB1, ABCC1 and ABCG2 from these groups. The pathological analysis further demonstrated that tumors treated with Se-MnP and OX@Se-MnP exhibited lower expression of ABCB1, ABCC1 and ABCG2, compared with those treated with OX