Fig. 8
Reproduced with permission from He et al. [146]. Copyright 2022, Ivyspring
Schematic illustration of SHIFT&DOX preparation and transarterial chemoembolization of HCC. A Superstable pure-nanomedicine formulation technology (SPFT) was used to produce nano-DOX with a smaller nanoparticle size and homogeneity. B Subsequently, nano-DOX was homogeneously dispersed into lipiodol via ultrasonication (US) to prepare the SHIFT&DOX. C The SHIFT&DOX was specifically deposited into hepatocellular carcinoma lesions through transcatheter embolization. This led to long-term DOX stability and slow drug release from lipiodol to improve treatment effects and safety of HCC.