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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Impaired autophagy-accelerated senescence of alveolar type II epithelial cells drives pulmonary fibrosis induced by single-walled carbon nanotubes

Fig. 2

SWCNTs impaired autophagic flux in AECIIs of mouse lung tissue. Mice were exposed to 40 μg SWCNTs by intratracheal instillation, then autophagy of the lung tissue was evaluated. A–D Western Blotting analysis of Atg5, LC3BI, LC3BII and p62 protein expressions (n = 3) in lung tissues of mice. E The LC3B expressions (n = 5) in lung tissues were evaluated by IHC on days 3, 7 and 28 upon SWCNTs administration (200×). F Immunostaining for LC3B and SP-C from SWCNTs-exposed lung tissues of mice on day 28 was detected by IF (200×). *P < 0.05 vs CTRL group

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Journal of Nanobiotechnology

ISSN: 1477-3155

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