Fig. 1From: In vivo toxicity evaluation of tumor targeted glycol chitosan nanoparticles in healthy mice: repeated high-dose of glycol chitosan nanoparticles potentially induce cardiotoxicityPreparation and characterization of CNPs. A The each drug, loadng capacity, injection dose, of the drug-loaded CNPs in previous studies. PTX; paclitaxel, DTX; docetaxel, CPT; camptothecin, DOX; doxorubicin, CDDP; cisplatin, Ce6; chlorin e6 and PpIX; Protophorphyrin IX. B Size distribution and morphology of CNPs in the clinically relevant highly concentrated aqueous condition (1.5, 3.375, 6.75, 13.5 or 20Â mg/1Â ml). The scale bar in TEM images indicates 200Â nm (n=5). C Size stability of different concentrations of CNPs in the mouse serum (n=5)Back to article page