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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: In vivo toxicity evaluation of tumor targeted glycol chitosan nanoparticles in healthy mice: repeated high-dose of glycol chitosan nanoparticles potentially induce cardiotoxicity

Fig. 2

Cellular uptake and cytotoxicity of CNPs. A Cellular uptake of CNPs in 4T1 breast cancer cells, H9C2 cardiomyocytes, L929 fibroblast and Raw264.7 macrophages in the condition of different dose and incubation time. B Quantitative analysis for the amount of cellular uptake of CNPs in 4T1, H9C2, L929 and Raw264.7 cells in the condition of different dose and incubation time (n = 5). C Cellular uptake of CNPs in the H9C2 cells at different temperature and after pretreatment of chlorpromazine or cytochalasin D. D Quantitative analysis for cellular uptake of CNPs in the H9C2 cells at different temperature and after pretreatment of chlorpromazine or cytochalasin D (n = 5). E The viability of 4T1, H9C2, L929 and Raw264.7 cells after treatment with CNPs for 24 h (n = 5). F Annexin V/PI staining of H9C2 cells after treatment with CNPs for 24 h (n = 5)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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