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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: In vivo toxicity evaluation of tumor targeted glycol chitosan nanoparticles in healthy mice: repeated high-dose of glycol chitosan nanoparticles potentially induce cardiotoxicity

Fig. 5

Cardiotoxicity evaluation after repeated high-dose of CNPs treatment. A Whole heart tissues stained with H&E after multi-dose of 10, 22.5 or 90 mg/kg CNPs. Right panel indicates the fluorescence imaging of heart tissues after treatments in the same protocol. Histological analyses were performed on day 7 after treatments. B, C Heart tissues stained with Masson’s trichrome after multi-dose of 10, 22.5 or 90 mg/kg CNPs. D Quantative analysis for the fibrotic areas (%) over whole region of heart tissues. Heart tissues were collected from the mice on day 7 after multi-dose of 10, 22.5 or 90 mg/kg CNPs (n = 5). E The levles of TNF-α, IL1b and IL-6 in heart tissues on day 7 after multi-dose of 10, 22.5 or 90 mg/kg CNPs

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Journal of Nanobiotechnology

ISSN: 1477-3155

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