Table 1 Characteristics of the three methods of SeNP synthesis for lung cancer
From: Theranostic applications of selenium nanomedicines against lung cancer
Production method | SeNPs characteristics | Advantages | Disadvantages | References |
|---|---|---|---|---|
Physical synthesis | • γ-radiation • Microwave radiation • Pulsed laser ablation in liquids (PLAL) | • Rapid and uniform production • Environmentally friendly high physical properties • Controlled and not easily contaminated by chemical reagents | • Low efficiency • Low yield • High energy consumption • Easy sample contamination • Uneven particle size | |
Biological synthesis | • Biological synthesis uses plant extracts, fungi and bacteria to synthesize biogenic SeNPs • Microbial synthesis refers to the reduction of other forms of Se to SeNPs through microbial metabolism products | • Safe, hypotonicity • Recyclable • Environmentally friendly • High stability | • Conditions are very strict, not very simple • Poor quality control • SeNPs surface composition unknown | |
Chemical synthesis | • Through REDOX reaction | • Simple process • Controllability • Stable chemical structure • Diameter of uniform | • High cost of production • Presence of toxic byproducts |