Fig. 3
From: Active targeting schemes for nano-drug delivery systems in osteosarcoma therapeutics
Bone tissue targeting scheme design and efficacy assessment of nano-drug delivery systems. a Representative fluorescence images of HAp crystal after incubation with RhB-labeled TNPs (upper panel) showing the interaction between HAp and targeted NPs. DIC: Imaging of HAp crystal. Copyright 2016, Scientific Reports. b Scheme of the HOS/MNNG and hydroxyapatite collagen co-culture model. c Confocal microscopy images of HOS/MNNG cells co-cultured with HAp and collagen matrix. Copyright 2022, Journal of Controlled Release. d Schematic represents the fabrication process of HNC using nanoprecipitation. Copyright 2017, Nanoscale. e Design of bone-targeted protein nanomedicine for the treatment of malignant bone tumors. f GPS or GPSP nanoparticles adsorbed on the HAp tablets. g Fluorescence images of tibias from healthy mice and bone tumor-bearing mice incubated with GPSCy5.5 and GPSCy5.5P, respectively. GP G5-PBA molecule, GPS GP/saporin complex. Copyright 2022, Bioactive Materials. h Schematic illustration of CPPA nanoparticles. i 3D micro-CT reconstruction of the tibias after treatment. Copyright 2020, Small