Fig. 8
From: Active targeting schemes for nano-drug delivery systems in osteosarcoma therapeutics
Peptide-related and cancer stem cell-related active targeting scheme design of nano-drug delivery systems. a Comparison between cellular uptake of targeted and nontargeted formulations. Copyright 2018, International journal of nanomedicine. b Schematic illustration for preparation of STP-NG/SHK, and RIP1- and RIP3-dependent cell necroptosis in primary tumor and lung metastasis. Copyright 2018, Theranostics. c NIR-II fluorescence images of 143B xenograft mice at different time points post injection of SPN-PT or SPN-SP. Scale bar = 1 cm. d Two-dimensional (upper) and three-dimensional (lower) PA imaging of 143B tumors in living mice injected with SPN-PT at different time points. Copyright 2022, Journal of nanobiotechnology. e Schematic description of evolutionary selection of osteosarcoma HOS cell/tissue dual-homing phage nanofibers from a phage library by a combination of in vitro and in vivo biopanning against osteosarcoma cells and tumor tissues. f Living image show the tumor targeting and retention of two-dimensional nanodiscs after 24 days of injection. Copyright 2022, Small. g The preparation procedure of SAL-NP or Ap-SAL-NP. Copyright 2015, International Journal of Nanomedicine. h Schematic illustration of anti-CD271 antibody conjugated HGNs. Copyright 2020, Nanotechnology