Active targeting schemes for nano-drug delivery systems in osteosarcoma therapeutics

Table 1 Examples of bone tissue targeting

Targeting ligand	Nanocarrier type	Agent	Cell lines	References
ALN	Liposomes	DOX	K7M2 OS cells 4T1murine breast cancer cells RAW264.7 murine monocyte-macrophage cells	[7]
	HPMA copolymer	TNP-470	K7M2 OS cells	[45]
	Nanoclusters	DOX	HOS/MNNG OS cells	[49]
	NPs	SPION	K7M2 OS cells	[50]
ZOL	NPs	Gemcitabine & Epirubicin	MG-63 cells	[53]
	NPs	DOX & DOXY	OS-732 cells	[54]
Pamidronate	Polylactide NPs	DOX	K7M3 OS cells and GFP-labeled K7M2 OS cells	[51]
Asp8	Micelles	DOX	Saos-2 OS cells	[63]
	NPs	Platinum-copper alloy	MDA-MB-231 cells	[65]
	Boronated polymer	Saporin	143B OS cells and MDA-MB-231 cells	[67]
PA	NPs	Cisplatin	MDA-MB-231 cells	[74]
	NPs	Platinum	NIH3T3 cells and PC-9 cells	[75]

ALN alendronate, ZOL zoledronate, PA phytic acid, NPs nanoparticles, DOX doxorubicin, SPION superparamagnetic iron oxide nanoparticle, DOXY doxycycline, OS osteosarcoma

ISSN: 1477-3155