Table 2 Examples of osteosarcoma cells targeting

Ligand CD80 and VEGF Antibody

NPs

Magnetic Iron Oxide

Rodent OSA cell line (ATCCTMNPO CRL-2836)

[98]

VEGF

NPs

Au &DOX

MG63‑Luc cells

[101]

RGD

NPs

AIBI&MnO2&TPP

MNNG/HOS OS cells

[115]

MTX

NPs

MTX & Zn²⁺

Saos-2 OS cell, MCF-7 and T47D human breast cancer cells

[129]

Folate

Nanotubes

MTX

CT26WT murine colorectal cancer, K7M2-WT OS cells and MC3T3-E1 pre-osteoblast cells

[121]

EGFR aptamer

NPs

Salinomycin

U2OS and MG63 OS cells

[135]

Trastuzumab

NPs

Trastuzumab & GO

MG63, HOS and 143B OS cells

[144]

Mannose

Nanocomposite

CD-siRNA

U2OS OS cells

[153]

2DG

Nanocomplexes

GQD

hFOB 1.19 osteoblastic cells and 143B OS cells

[156]

Fructose

NPs

Mn²⁺

143B OS cells and MC3T3-E1 cells

[160]

HA & ALN

Micelles

Curcumin

MG-63 OS cells and human osteoblast cells

[167]

HA

NPs

CDDP&DOX&R848

K7M2 OS cells Bone marrow-derived DCs and bone marrow-derived macrophages

[166]

YSA-peptide

Liposomes

DOX

Saos-2 OS cells and primary bone cells

[176]

STP

Nanogel

Shikonin

hFOB1.19 osteoblast cells and 143B OS cells

[179]

peptide PT

NPs

Semiconducting polymer (PCPDTBT)

4T1 murine mammary carcinoma cells, 143B, MG63 OS cells

[189]

OTP

Nanodiscs

Nanodiscs

HOS OS cells, HUVECs, MLO-Y4, and MC-3T3-E1 cells

[192]

CD133 aptamers

NPs

Salinomycin

Saos-2, U-2 and MG-63 OS cells

[15]

CD271 monoclonal antibody

Nanospheres

HGNs

Saos2 and MNNG/HOS OS cells

[207]

HOS CMs

NPs

IR780

HOS, MG63, 143B and K7M2 OS cells; 4T1 breast cancer cells and A549 non-small-cell lung cancer cells

[216]

WELL5 CMs

NPs

MTX & FUDR

WELL5 and MG63 OS cells; HUVEC cells

[217]

TPP

Nanocomposites

ICG

MG63 OS cells

[229]

NLS peptides

NPs

DOX

Saos-2 OS cells

[231]

CPP&NLS peptides

NPs

Au

143B OS cells

[234]