Fig. 7

Anti-wAMD efficacy in vivo. A FFA images of wAMD model mice treated with different formulations at day 14 and B quantitative fluorescence leakage area for each spot calculated by ImageJ. Data are shown as mean ± SD, n = 12. ***P < 0.001 vs Model; ^###P < 0.001 vs R + B; ^&&&P < 0.001 vs Bor/RB-M; ^@@P < 0.01 vs RB-M@TRG. C IB4 staining of the RPE-choroid complex layer. The part circled with red is the CNV area, and the part circled with white is the optic disc. The bar is 200 μm. D Quantitative CNV area calculated by ImageJ. Data are shown as mean ± SD, n = 12. **P < 0.01, ***P < 0.001 vs Model; ^###P < 0.001 vs R + B; ^&&&P < 0.001 vs Bor/RB-M; ^@@P < 0.01 vs RB-M@TRG. E OCT images of wAMD model mice treated with different formulations at day 14. The part circled in red delineates the rupture and bulge in the subretinal space