Scheme 1

Schematic preparation and sustained retina drug delivery of Bor/RB-M@TRG. Bor/RB-M@TRG composed of Bor/RB-M and a temperature-responsive hydrogel network is prepared by “one-pot” synthesis and physical crosslinking successively. Bor/RB-M@TRG is able to be colonized in the vitreous for at least 14 days and sustainedly release Bor/RB-M to the RPE, thereby synergistically cutting off the CNV formation driven by the “angiogenesis-oxidative stress” loop