Fig. 3
From: Ratiometric electrochemical OR gate assay for NSCLC-derived exosomes
Construction and feasibility verification of the biosensor. A Electrochemical impedance spectroscopy and B cyclic voltammetry curves of the bare electrode (curve a), bare + T1/T2 (curve b), bare + T1/T2 + S1-MB/S2-MB (curve c), bare + T1/T2 + S1-MB/S2-MB + B1/B2 (curve d), and bare + T1/T2 + S1-MB/S2-MB + B1/B2 + H1-Fc/H2-Fc (curve e). C Differential pulse voltammetry (DPV) curves under different experimental conditions. D DPV peak current of IMB and IFc under different signal inputs. E Validation of OR logic gate in the presence/absence of epithelial cell adhesion molecule (EpCAM) and carcinoembryonic antigen (CEA). F Optimization of incubation time for exosome captured by aptamers. The concentrations of exosomes were set as 105, 2 × 106, and 2 × 108 particles µL−1, respectively. G Single MB signal (IMB), single Fc signal (IFc), and H IFc/IMB ratio signal for exosome detection. The concentrations of exosomes were set as 103, 105, and 107 particles µL−1, respectively