Fig. 10
Poly (lactic-co-glycolic acid)-based intravitreal drug delivery systems. A The scheme of microspheres elaboration via the novel solid-in-oil-in-water (S/O/W) method. B The scanning electron microscopic image of GDNF-loaded microspheres. C Elaboration process of the examethasone/melatonin/coenzyme Q10-loaded PLGA microspheres (DMQ-MSs). D Scanning and transmission electron microscopic images of empty MSs and drug-loaded MSs. Particle size distributions of different MSs are also presented. (E) The density of RGCs in naïve retinas (ai and aii), untreated retinas (b), empty MSs-treated retinas (c), mixture MSs-treated retinas (d), and DMQ-MSs-treated retinas. Each red box = 1 mm2. (f) and (g) present statistical analyses of IOP change and RGCs density respectively after different treatments on ocular hypertension models. A, B Reprinted from Ref. [102] with permission from Elsevier. C—E Reprinted from Ref. [179] with permission from Elsevier