Fig. 11

Dendrimers-based intravitral delivery system. A A schematic illustration of the manufacture of copolymer nanoparticles (unimNPs) conjugated with the RGC-targeting CTB (CTB-unimNPs) for target delivery of DHEA to the RGCs. B Transmission electron microscopic images of the unimNPs. C In vitro DHEA release profiles from DHEA-loaded non-targeted (unimNPs) and targeted NPs (CTB-unimNPs). D Representative images showing RGCs density (BRN3A-positive) in the retinas collected at day 7 and day 14 after intravitreal injection of CTB-unimNPs or DHEA-loaded CTB-unimNPs. Scale bar = 100 μm. E Statistical analyses of RGCs amount in the retinas treated by CTB-unimNPs and DHEA-loaded CTB-unimNPs. Reprinted from Ref. [180] with permission from Elsevier