Intraocular nano-microscale drug delivery systems for glaucoma treatment: design strategies and recent progress

Shen, Yuening; Sun, Jianguo; Sun, Xinghuai

doi:10.1186/s12951-023-01838-x

Journal of Nanobiotechnology

Table 2 In vivo studies on intraocular drug delivery systems targeting glaucomatous symptoms (data accessed in February of 2023)

From: Intraocular nano-microscale drug delivery systems for glaucoma treatment: design strategies and recent progress

Year	Drug carriers	Drug delivered	Route	Animal model	Main in vivo effect	References
2006	PLGA nanospheres	PEDF peptide	IVJ	Retinal I/R injury mice	Sustained release	[182]
2007	PLGA microspheres	GDNF	IVJ	DBA/2 J mice	Sustained release	[177]
2007	PLGA microspheres	GDNF	IVJ	OHT rat	Sustained release	[178]
2011	PLGA microspheres	GDNF + vitamin E	IVJ	OHT rat	Sustained release	[102]
2011	Gelatin-grafted-PNIPAAm	Pilocarpine	Intracameral injection	OHT rabbit	Thermo- responsive; sustained release	[166]
2011	PLGA microspheres & nanospheres	AG1478	IVJ	ONC rat	Sustained release	[146]
2011	Poly (γ-glutamic acid) NPs	Dexamethasone	IVJ	NMDA induced retinal injury rat	Sustained release	[183]
2015	HSA NPs	Brimonidine	IVJ	ONC rat	Sustained release	[181]
2015	PLGA NPs and MPs	Connexin43 peptide	IVJ	Retinal I/R injury rat	Sustained release	[184]
2015	Nanosponge	Brimonidine; Travoprost; Bimatoprost	IVJ	OHT mice	Sustained release	[185]
2016	PCL	DE-117	Intracameral delivery	Normal rabbit	Sustained release	[170]
2016	PLA microspheres	Brimonidine	Supraciliary delivery	Normal rabbit	Sustained release	[84]
2017	PAMAM–PVL–PEG	Dehydroepiandrosterone	IVJ	NMDA induced retinal injury mice	Target delivery; sustained release	[180]
2017	Gelatin-coated MSNs	Pilocarpine	Intracameral injection	OHT rabbit	Sustained release	[168]
2017	GA-grafted-gelatin-PNIPAAm	Pilocarpine	Intracameral injection	OHT rabbit	Thermo- responsive; sustained release	[186]
2017	PCL NPs	Pilocarpine	Intracameral injection	OHT rabbit	Sustained release	[160]
2018	PCL	DE-117	Intracameral delivery	Normal rabbit	Sustained release	[123, 170]
2018	PEG-PSA MPs	Dorzolamide	IVJ	OHT rat	Sustained release	[187]
2018	HA-coated HSA NPs	Connexin43 peptide	IVJ	Retinal I/R injury rat	Sustained release	[188]
2018	Sul − PSHU − PNIPAAm	CNTF	IVJ	ONC rat	Thermo- responsive; sustained release	[189]
2019	PLGA microspheres	Dexamethasone + melatonin + coenzyme Q10	IVJ	OHT rat	Sustained release	[179]
2019	Chitosan-grafted- PNIPAAm	Pilocarpine + RGFP966	Intracameral injection	OHT rabbit	Thermo- responsive; sustained release	[190]
2019	PAMAM-gelatin-grafted -PNIPAAm	Pilocarpine + ascorbic acid	Intracameral injection	OHT rabbit	Thermo- responsive; sustained release	[167]
2020	LAPONITE®	Brimonidine	IVJ	OHT rat	Sustained release	[82]
2020	PAMAM	Superoxide dismutase	IVJ	Retinal I/R injury rat	Intracellular delivery	[191]
2020	Hollow PLA NPs	Pilocarpine	Intracameral injection	OHT rabbit	Sustained release	[81]
2020	PEG400	Tafluprost	IVJ	ONT rat	Sustained release	[192]
2020	PEG-PSA NPs	Brinzolamide + miRNA-124	IVJ	ONC mice	Sustained release	[193]
2021	Polydopamine NPs	Brimonidine	IVJ	ONC mice	Sustained release	[194]

PLGA, poly (lactic-co-glycolic acid); PEDF, pigment epithelium-derived factor; IVJ, intravitreal injection; I/R, ischemia–reperfusion; GDNF, glial cell line-derived neurotrophic factor; OHT, ocular hypertension; PNIPAAm, poly (N-isopropylacrylamide); AG1478, 4-(3-chloroanilino)-6,7-dimethoxyquinazoline (a tyrosine kinase inhibitor of the epidermal growth factor receptor); ONC, optic nerve crush; NPs, nanoparticles; NMDA, N-methyl-D-aspartate; HSA, human serum albumin; MPs, microparticles; PCL, poly (ε-caprolactone); PLA, poly (lactic acid); PAMAM, poly (amidoamine); PVL, polyvalerolactone; PEG, polyethylene glycol; HA, hyaluronic acid; Sul − PSHU − PNIPAAm, sulfonate functionalized poly (serinol hexamethylene urea) (PSHU) conjugated PNIPAAm; CNTF, cilliary neurotrophic factor; MSNs, mesoporous silica nanoparticles; GA, gallic acid; PEG-PSA, Poly (ethylene glycol)-co-poly (sebacic acid); ONT, optic nerve transection

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