Fig. 11

In vivo antitumor effects of AR-NADR. A Treatment regimen. B Body weight of mice after treatment with PBS, AR-NA, AR-NAR, DDP, AR-NAD, and AR-NADR. C Photographs of representative animals in each group. D Changes in tumor volume after various treatments. Tumor volumes were normalized to baseline values. E (a) H&E staining, (b)TUNEL staining and (c) NOR1 IHC of tumor tissues at 14 days after injection with various treatments. F NOR1 protein levels by Western blot analysis upon different treatments. Semiquantitative assessment of Western blot bands. (a) PBS, (b) AR-NA, (c) AR-NAR, (d) DDP, (e) AR-NAD, and (f) AR-NADR. Scale bar: 50 μm. Data are presented as the means ± SD (n = 3) (Intergroup comparisons: *p < 0.05, ***p < 0.001)