Fig. 1

Characterization of the amphilic copolymer and nanoparticles. A ¹H NMR of P[Ph(ox)]-P[MT]-PEG. B Hemolytic assay of the copolymer. C Schematic illustration of PTX@PoxMTP NPs disassembly in response to ROS and esterase; (D) Particle size distribution of blank (a), PTX loaded (b) and H₂O₂ treated nanoparticles (c) by DLS and TEM, scale bar = 100 nm; (E) Stability of PTX@PoxMTP NPs in the absence and presence of 1 mM H₂O₂. (F and G) PTX and 1-MT release under different conditions (n = 3)