Fig. 6

In vivo biodistribution and antitumor evaluation. A In vivo biodistribution of DiR labelled nanoparticles in 4T1 tumor bearing mice. B–C Fluorescence images and analysis of excised major organs and tumors at 48 h after intravenous administration. D The timeline of antitumor evaluation. E Body weight of mice received different treatments. F–H Tumor volume, weight and inhibition rate (TGI) in different treatment groups. I Representative tumor images from different groups. J HE and Ki67 staining of tumor sections. Scale bar = 100 μm. K–L Representative images, HE staining and metastatic nodules of lungs from different groups. Scale bar = 100 μm. *P < 0.05, **P < 0.01 and ***P < 0.005