Fig. 6

Interaction and metabolism between RBC-NPs and GST-ETX in vivo. A Schematic illustration of the experiments. Two groups of mice were injected with 5 ng GST-ETX intravenously, and 10 min later, mice in the treatment group were injected with 2 mg DiR-RNPs intravenously and mice in the positive control group were injected with PBS intravenously. Blood and organs were analyzed at 5 min, 24 h, 48 h and 72 h in vitro. B The fluorescence level of the DiR in blood (n = 3). C The fluorescence level of Cy5.5 in blood (n = 3). D In vitro fluorescence images of DiR in liver and spleen, E radiant efficiency of the DiR in liver and spleen (n = 3). F In vitro fluorescence images of Cy5.5 in liver and spleen. G Radiant efficiency of Cy5.5 in liver and spleen (n = 3). The positive control group was injected with Cy5.5-ETX and PBS, the treatment group was injected with Cy5.5-ETX and DiR-NPs. Data are presented as the mean ± SD