Schematic diagram of the construction of CEAS and its application to multimodal detection. A Construction of the Controlled Enzyme Activity Switch (CEAS). B Schematic representation of a CEAS system respond to protein targets and deconstruct into active catalytic modes. b CEAS coupled with RCA, SDR is sensitive and rapid for nucleic acid target detection. C Rapid and efficient application of CEAS multimodal biosensing detection in practice. Gu. Tem. guidance template, Tar. Res. (Apt.) target response (aptamer), Id.pro identification probe