Fig. 6

Exos@SFMA efficiently modulated immune dysregulations. (a) Schematic illustration of modulating immune pathogenesis by inhibiting Tfh cell polarization and B cell development in RA via Exos@SFMA treatment. (b-d) Modulation of immune pathogenesis in RA development. Proportions and cell number of Tfh cells (b), germinal center B cells (c), and plasma cells (d) in popliteal lymph nodes (PLN) of CIA mice treated with PBS, OE-MSC-Exos or Exos@SFMA on day 42 after the first immunization. Values represent means ± S.D. (n = 4). *P < 0.05, **P < 0.01