Fig. 8

Anti-inflammatory and angiogenesis effect analysis of the hybrid hydrogels. Immunohistochemistry staining images of A IL-6, TNF-α on day 3 (scale bar: 200 μm), C VEGF, TGF-β on day 7 (scale bar: 100 μm) and E CD 31 at the wound sites on day 14 post-treatment (scale bar: 100 μm). Red arrows represent blood vessels. Quantitative analysis of the expression level of B IL-6, TNF-α and D VEGF, TGF-β. F Quantitative results of blood vessels on day 14 post-operation. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001