Fig. 4
The distribution and therapeutic efficacy of P-IDI on 4T1 Tumor-bearing Mice. a 2D ultrasonic (US), PA and merge images of tumor tissues from pre- and post-injection of P-IDI (10 mg IDI/kg). b The corresponding PA amplitude of tumor tissues from (a). c Thermal images of 4T1 tumor-bearing mice with different treatments. d Temperature of 4T1 tumors upon laser irradiation as a function of irradiation time (1064 nm, 1 W/cm2). e Tumor growth curves of 4T1 tumor-bearing mice after various treatments (n = 4). f Images of representative tumors taken from mice in different formulations after the 21-day treatment period. g Final tumor weights of 4T1 tumor-bearing mice exposed to different formulations after different treatment. h H&E staining images of tumor sections harvested from 4T1 tumor-bearing mice (PBS, Laser only, P-IDI, P-IDI + Laser) after treatments. Scale bar: 100 µm. Statistical significance was assessed via unpaired two-sided Student t-test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 versus control