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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: A TMVP1-modified near-infrared nanoprobe: molecular imaging for tumor metastasis in sentinel lymph node and targeted enhanced photothermal therapy

Fig. 3

The characteristics of TMVP1-ICG-NPs. (A) The appearance of TMVP1-ICG-NPs and the control ICG-NPs. (B-C) TEM images of TMVP1-ICG-NPs and ICG-NPs (scale bar 500 nm). (D) Size stability of TMVP1-ICG-NPs and ICG-NPs stored in phosphate-buffered saline (PBS, pH 7.4) at 4℃. (E-F) The size distribution of TMVP1-ICG-NPs and ICG-NPs was determined by DLS. (G) UV/Vis spectra of free ICG, ICG-NPs, and TMVP1-ICG-NPs in PBS. (H) Cytotoxicity of different ICG concentrations (6.25, 12.5, 25, 100, and 200 µg /mL) in TMVP-ICG-NPs in 4T1, MS751, and HaCaT cells after 24 h of incubation. (I) Blood metabolism characteristics of TMVP1-ICG-NPs and free ICG in SD rats via tail vein injection of 500 µg of equivalent ICG. Values of p < 0.05 were considered significant (ns: no significance, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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