Fig. 2From: The application of extracellular vesicles in colorectal cancer metastasis and drug resistance: recent advances and trendsDiagram of EVs transport. EVs secreted by tumor and stromal cells: a captured in CRC tissues; b metastasized to metastatic sites via the blood circulation; c captured by vascular endothelial cells. EVs undergo (i) endocytosis or (ii) fusion with the recipient cells and release bioactive substances to activate signaling, ultimately leading to CRC metastasis and drug resistanceBack to article page