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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: The application of extracellular vesicles in colorectal cancer metastasis and drug resistance: recent advances and trends

Fig. 3

The role of EVs in CRC. Donor cells secrete EVs into TME: a EVs act on immune cells to regulate immunosuppression; b EVs are taken up by recipient cells to promote angiogenesis and EMT; c EVs induce macrophages and fibroblasts transformation to favor CRC growth; d EVs are taken up by CRC cells to promote proliferation and chemoresistance; e EVs are also taken up by donor cells to exert some effect; f the microacidic and hypoxic environment in TME could accelerate the release of EVs from donor cells

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Journal of Nanobiotechnology

ISSN: 1477-3155

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