Fig. 2
From: Recent development of surface-enhanced Raman scattering for biosensing
© 2017, American Chemical Society. B reprinted with permission from Ref. 67, © 2018, American Chemical Society. C and D reprinted with permission from Ref. 68, © 2012, American Chemical Society
SERS biosensor based on antibody/antigen. A Sequential SERS-based assay process for the simultaneous detection of f-PSA and c-PSA. [63] B Schematic illustration of MANC preparation for J1 peptide detection. In the presence of J1, MANC-on-nanoplate structures are constructed and SERS signals of MGITC are observed. [67] C Mechanical deformation in an anti-H1/4-ATP sensor. (i) A pure 4-ATP SAM, (ii) Conjugation of anti-H1 leads to stretching of the 4-ATP molecule, (iii) Binding of H1 leads to reductions in the center-to-center distance between antibody molecules, thereby leading to mechanical relaxation in 4-ATP. [68] D Average SERS spectra at different antigen concentrations, showing shifts at (i) 865 and (ii) 1000 cm−1. [68] A reprinted with permission from Ref. 63,