Fig. 3
From: Recent development of surface-enhanced Raman scattering for biosensing
© 2020, Elsevier. B reprinted with permission from Ref. 75, © 2021, American Chemical Society. C reprinted with permission from Ref. 76, © 2008, John Wiley and Sons. D reprinted with permission from Ref. 77, © 2021, International Journal of Molecular Sciences
SERS biosensor based on aptamer. A Schematic representation of SERS aptasensor for S. Sonnei determination utilizing dual-functional metal complex-ligated gold nanoparticles dimer. [74] B (i) Sequential procedure for fabricating two types of aptamer-modified NP SERS tags. (ii) Procedure for fabricating a dual MC sensor for MC-LR and MC-RR. [75] C Schematic diagram for the preparation and analytical principle of the aptameric sensor for cocaine. [76] D Schematic representation of aptasensor setup. Aptamer-functionalized AgNP were mixed with a labeled aptamer in buffered saline providing AgNP aggregates (ii). The aggregates were mixed with target viruses (iii) resulting in weaker SERS signals or with off-target biologicals (iv) losing SERS effect due to the elimination of the labeled aptamer from AgNP aggregates. [77] A reprinted with permission from Ref. 74,