Fig. 6
From: Recent development of surface-enhanced Raman scattering for biosensing
© 2021, American Chemical Society. Figure B reprinted with permission from Ref. 126, © 2021, American Chemical Society
Label-SERS for the detection of SARS-CoV-2. A Schematic illustration of the quantitative evaluation of SARS-CoV-2 using the SERS-based aptasensor. After SARS-CoV-2 lysates release the target spike proteins, they are recognized by the aptamer DNAs on the AuNPs surfaces. The spike protein-bound aptamers move away from the AuNPs surfaces, leading to a decreased Raman peak intensity of Cy3 reporters [107]. B Experimental procedure for diagnosing the infectiousness of SARS-CoV-2 [126]. C Simple illustration of SERS-LFA platform for detecting SARS-CoV-2 antigen. Liquid move via capillary flow on the nitrocellulose membrane. When SARS-CoV-2 antigens are present, they bind to the labeled AuNPs and continue to move until they are captured by the immobilized antibody 1. The labeled control antibodies comigrate until they are captured at the control band. A reprinted with permission from Ref. 107,