Fig. 8

Cancer cell targeting and spectroscopic detection by using antibody-conjugated SERS nanoparticles. A Schematic illustrations (i) for the fabrication of three different Raman reporter-adsorbed Au–Ag core–shell nanoparticles and the conjugation of PEGylated antibodies on the surface of the above Au–Ag core–shell nanoparticles. [148] B The evaluation of before and after treatment towards the tumors based on SERS imaging. [148] (i) Control group: SERS imaging of right axilla of healthy nude mice and organs. (ii) Tumor group: SERS imaging of breast tumor and organs without any treatment. (iii) Drug therapy group: SERS imaging of breast tumor and organs after tamoxifen treatment for 15 days. (iv) Surgery therapy group: SERS imaging of breast tumor and organs after surgery. Figure A and Figure (B reprinted with permission from Ref. 148,