Fig. 4

FOXM1 and EVs -mediated gene editing. A Analysis of FOXM1 expression in HCC tumor and normal tissue using TCGA database. B Overall survival (OS) curves of HCC patients and C sorafenib treated HCC patients. D Cas9:sgRNA-mediated indels were assessed by T7E1 assay and corresponding protein inhibition level was evaluated through western blotting. E Schema of dual sgRNA plasmid induced cleavage and F reduction of targeted gene expression level was analyzed using different quantity combination of EVs and sgRNA by western blot along with G related indels were examined using T7E1 assay