Fig. 6

Knockout of IQGAP1/FOXM1 upgrades sorafenib therapeutic effect. A PI3K/Akt and MAPK/ERK signaling related protein expression level were examined using western blotting and B–H corresponding quantitative protein expression results. I Nuclear localization of β-catenin was analyzed with immunostaining. Scale bar: 1 μm. Mock group was used as control. Data are expressed as mean ± SD. n = 3; *p < 0.05, ***p < 0.001, by two-way ANOVA