Fig. 7

Anti-cancer effects of sgIF loaded HLC9-EVs in combination with sorafenib treatment in Huh7 xenografts. A Tumor sizes were measured once in 4 days post the initial injection. Group Mock was used as control. Data are expressed as mean ± SD. n = 5; *p < 0.05, **p < 0.01 by student’s t-test. B Display of excised tumors on day 21 post the initial treatment. Scale bar: 1 cm. n = 5. C Western blotting analysis of IQGAP1/FOXM1 expression and D relative protein expression level was quantified. E Immunofluorescence staining of IQGAP1/FOXM1 in excised tumor samples. Scale bar: 100 μm. Group Mock was used as control. Data are expressed as mean ± SD. n = 3; *p < 0.05, ***p < 0.001 by two-way ANOVA