Fig. 1

Characterization of MCMD NPs. A The detailed synthesis route of MCMD NPs. B The FITR of MCMD (a: sMMP9, b: sMMP9-DOX, c: CpG- sMMP9-DOX, d: MPLA-CpG-sMMP9-DOX). C The agarose gel electrophoresis of free CpG and CpG-sMMP9-DOX. D The agarose gel electrophoresis of CpG-sMMP9-DOX and MPLA-CpG-sMMP9-DOX. E The typical TEM image of MCMD NPs. F The size distribution of MCMD NPs in PBS. G The size distribution of MCMD NPs against the MMP9 enzyme or not. H The DOX release profile from MCMD NPs with MMP9 enzyme or not. Data were expressed in the form of mean ± SD (n = 3)