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Table 2 Modulating hydrogel composition to tailor hydrogel gelation temperature at different pH, mechanical and degradation properties

From: Nano hydrogel-based oxygen-releasing stem cell transplantation system for treating diabetic foot

Polymer

Composition*

(mol%)

Gelation Temp

(℃)

Stiffness

(kPa)

Tensile strain**

(%)

Weight loss***

(%)

PAA1

72/13/15

33.5 (pH 6.8)

36.5 ± 6.9

> 300

15.7 ± 3.0

39.6 (pH 7.4)

PAA2

78/13/9

35.7 (pH 6.8)

5.4 ± 1.9

> 300

36.1 ± 3.5

41.3 (pH 7.4)

PAA3

77/8/15

30.3 (pH 6.8)

52.6 ± 2.3

> 300

5.8 ± 1.6

39.3 (pH 7.4)

  1. *NIPPAm/PAA/macromer (HEMAPTMC) ratio. The number of TMC unites in HEMAPTMC is 2; **Out of strain range of the testing equipment. *** after 8 weeks in PH 6.8 buffer at 37 ℃