Fig. 1

Composition and structure of liposome vaccines. A Chemical structures of 4S, DPPC, CH, DOPC and PBS57. 4S is a lipid-modified CDG biomarker that can be loaded onto liposome membranes. DPPC, DOPC and CH are the main components of liposomes. Adjuvant PBS57 is added to enhance the switching of the antibody class from IgM to IgG. B Schematic structures of LP-4S, NLP, NLP-4S and NLP-4S-PBS57 liposome vaccines. LP-4S is prepared by DPPC, CH and loaded with CDG biomarker antigen 4S. NLP is prepared by DOPC and CH as the blank liposome. NLP-4S is prepared by DOPC, CH and loaded with CDG biomarker antigen 4S. NLP-4S-PBS57 is prepared by further loading PBS57 adjuvant into NLP-4S.